Haplotypes of VKORC1, NQO1 and GGCX, their effect on activity levels of vitamin K-dependent coagulation factors, and the risk of venous thrombosis.
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چکیده
منابع مشابه
Polymorphisms in VKORC1 and GGCX are not major genetic determinants of vitamin K-dependent coagulation factor activity in Western Germans.
Thromb Haemost 2009; 102: 418–420 Dear Sir, Several vitamin K-dependent coagulation factors require γ-carboxylation for biological activity. This posttranslational modification is performed by the endoplasmatic reticulum (ER) enzyme γ-glutamyl carboxylase (GGCX), which depends on vitamin K hydroquinone as an electron donor. In this process, vitamin K hydroquinone is oxidised to vitamin K epoxid...
متن کاملVKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo.
Vertebrates possess 2 proteins with vitamin K oxidoreductase (VKOR) activity: VKORC1, whose vitamin K reduction supports vitamin K-dependent (VKD) protein carboxylation, and VKORC1-like 1 (VKORC1L1), whose function is unknown. VKD proteins include liver-derived coagulation factors, and hemorrhaging and lethality were previously observed in mice lacking either VKORC1 or the γ-glutamyl carboxylas...
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Background and Objectives: The aim of the present study was to report a case of cerebral venous thrombosis (CVT) folowing consumption of the oral contraceptive pills with high estrogen levels. Case Report: A 35-year-old woman presenting a headache was diagnosed with thrombosis in the upper sagittal, sigmoid and transverse veins, by CT SCAN, MRI and MRV of the brain. Conclusion: The chance ...
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Low plasma level of vitamin D is linked to the increased risk of cardiovascular diseases such as hypertension, diabetes, dyslipidemia and peripheral vascular diseases. Vitamin D deficiency is a worldwide problem that involves Iranian population. To the best of our knowledge, this was the first investigation on venous thromboembolism (VTE) subjects that assessed the correlation of vitamin D leve...
متن کاملPlasma Vitamin D Status and Its Correlation with Risk Factors of Thrombosis, P-selectin and hs-CRP Level in Patients with Venous Thromboembolism; the First Study of Iranian Population
Low plasma level of vitamin D is linked to the increased risk of cardiovascular diseases such as hypertension, diabetes, dyslipidemia and peripheral vascular diseases. Vitamin D deficiency is a worldwide problem that involves Iranian population. To the best of our knowledge, this was the first investigation on venous thromboembolism (VTE) subjects that assessed the correlation of vitamin D leve...
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عنوان ژورنال:
- Thrombosis and haemostasis
دوره 106 3 شماره
صفحات -
تاریخ انتشار 2011